对与代谢功能障碍相关的脂肪性肝病的心血管评估
Daniel R Wang1, Pouyan Famini2, Kamran Shamsa1
1Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Journal of clinical gastroenterology
|June 6, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 显著增加了心血管疾病 (CVD) 的风险,这是由于胰岛素抵抗和肥胖等共同因素. 综合护理对于管理这些相互关联的疾病和减少患者死亡率至关重要.
科学领域:
- 肝病学和心脏病学.
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 影响全球超过25%的成年人.
- MASLD的进展可能导致严重的并发症,如肝硬化和肝细胞癌.
- MASLD与心血管疾病 (CVD) 有共同的风险因素和病理生理机制.
研究的目的:
- 探索MASLD和心血管疾病之间的复杂关系.
- 突出共同的风险因素和潜在的机制.
- 强调需要为高心血管风险的MASLD患者提供综合,多学科的护理.
主要方法:
- 本综述综合了有关MASLD和CVD的当前研究.
- 它检查了共同的风险因素,包括胰岛素抵抗,肥胖,脂质不良和高血压.
- 该综述分析了常见的病理生理路径,如葡萄糖代谢受损和血管炎症.
主要成果:
- 患有MASLD的患者表现出显著增加心血管事件的风险.
- 诸如内皮功能障碍和炎症等共享机制有助于增加这种风险.
- 种族和民族差异使MASLD和CVD的管理变得复杂.
结论:
- MASLD和CVD紧密交织在一起,共享共同的风险因素和机制.
- 综合,多学科的护理对于管理MASLD患者的心血管风险至关重要.
- 早期诊断,风险分层和综合管理对于改善结果和减少死亡率至关重要.
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