光学连贯断层扫描和血管造影揭示了儿科发病多发性硬化症早期视网膜变化
Selda Celik Dulger1, Fatma Bagci2, Ismail Solmaz2
1Department of Ophthalmology, Ankara Etlik City Hospital, Halil Sezai Erkut Street No. 5, Yenimahalle, Ankara, Turkey. drsldclk@gmail.com.
European journal of pediatrics
|June 6, 2025
概括
光学连贯断层扫描 (OCT) 和OCT血管扫描 (OCT-A) 显示儿科多发性硬化症 (MS) 患者的视网膜神经纤维层 (RNFL) 和节细胞内状层 (GC-IPL) 变薄. 斑点和周围斑点区域的血管密度下降与视神经炎有关.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 儿科 儿科 儿科
背景情况:
- 定量视网膜血管测量可以作为多发性硬化症 (MS) 进展的潜在生物标志物.
- 大多数OCT和OCT-A研究集中在成年多发性硬化症患者身上,对儿科患者的研究有限.
研究的目的:
- 调查儿科发病多发性硬化症 (POMS) 的光学连贯性断层扫描 (OCT) 和OCT血管学 (OCT-A) 参数的变化.
- 在POMS中识别视网膜神经纤维和结节细胞损失,独立于视神经炎.
- 为了证明光神经炎的POMS患者的斑点和周周血管密度降低.
主要方法:
- 展望横截面研究涉及37名POMS患者和36名健康对照 (HC).
- 对POMS眼睛进行了OCT和OCT-A扫描,分为具有 (MS+ON) 和没有 (MS-ON) 视神经炎史的眼睛.
- 视网膜神经纤维层 (RNFL) 厚度,质细胞内状层 (GC-IPL) 厚度和不同视网膜 (RPC, SCP, DCP) 的血管密度 (VD) 的比较.
主要成果:
- 与HC相比,RNFL厚度在MS+ON眼睛 (三段) 和MS-ON眼睛 (时间段) 中减少.
- 与大多数象限中的HC相比,GC-IPL厚度在MS+ON和MS-ON眼睛中显著较薄.
- 与MS-ON和HC相比,MS+ON眼睛的辐射周毛细血管 (RPC) 中血管密度 (VD) 显著较低.
- 与MS-ON和HC相比,表面毛细管 (SCP) 中的整体和周围的VD在MS+ON眼睛中明显较低.
- 两组之间没有观察到深毛细管 (DCP) VD或状血管区域 (FAZ) 大小的显著差异.
结论:
- 在POMS患者的OCT-A发现表明,与视神经炎相关的黄斑和周围细胞血管密度降低.
- GC-IPL和RNFL的稀薄发生在POMS眼睛中,无论视神经炎病史如何,视神经炎导致更明显的稀薄.
相关概念视频
Photoreceptors and Visual Pathways
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...


