中部加利福尼亚州的Coccidioides真菌病:十年的经验
Sang Jo Hwang1, Mohamed Fayed2, Marilyn Mitchell3
1Division of Infectious Disease, Department of Medicine, UCSF Fresno, University of California, San Francisco, 155 N Fresno St, Suite 307, Fresno, CA, USA.
Mycopathologia
|June 6, 2025
概括
菌菌病是一种严重的散播性菌菌症并发症,死亡率高. 使用真菌特异性培养物的早期诊断和及时的安福特里辛B治疗对于改善特有地区的结果至关重要.
科学领域:
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
- 临床医学 临床医学
背景情况:
- 菌菌病,一种严重的散播性菌菌病的表现,死亡率很高.
- 来自加利福尼亚州圣若金山谷的最新数据有限,这是一个具有高度特有性的地区.
- 本研究描述了Coccidioides真菌病患者的临床特征,危险因素和结果.
研究的目的:
- 在中部加利福尼亚州描述Coccidioides真菌病.
- 为了确定与Coccidioides真菌病相关的危险因素.
- 评估Coccidioides真菌病的治疗结果和治疗策略.
主要方法:
- 从2015年至2025年在第三级护理中心对Coccidioides真菌病例的回顾性审查.
- 收集的数据包括人口统计,临床表现,诊断,治疗和结果.
- 使用EORTC/MSG标准对传播性真菌感染进行分类的病例.
主要成果:
- 确定了11名患有C. immitis真菌病的患者;平均年龄40岁,64%男性.
- 危险因素包括先进的艾滋病毒/艾滋病,自身免疫性疾病,ESRD的糖尿病,慢性酒精使用和怀孕.
- 观察到高死亡率 (91%),50%在7天内死亡;诊断延迟和积极治疗不足.
结论:
- 菌菌病是一种罕见但严重的扩散性菌菌病的并发症.
- 具有高真菌负担和多器官传播的爆发性感染是这些病例的特征.
- 提高警,早期的真菌特异性诊断和及时的安二乙治疗可能会改善结果.
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