帕金森病中大脑小脑大规模网络连接:与情绪,认知和衰老效应的关联
Chentao He1,2,3, Zhenzhen Chen1,4, Mengfei Cai1,5
1Department of Neurology, Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, 510080, China.
Brain imaging and behavior
|June 6, 2025
概括
帕金森病 (PD) 涉及大脑小脑功能连接的改变,影响认知和情绪症状. 小脑和突出网络之间的连接性减少与患者的认知衰退和抑郁症有关.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 新出现的证据表明小脑与帕金森病 (PD) 有关.
- 在PD中,小脑和皮层-亚皮层网络之间的内在功能连接性尚未得到充分理解.
- 大脑小脑的变化可能会导致PD的运动,认知和情绪症状.
研究的目的:
- 为了研究帕金森病 (PD) 中小脑功能网络的改变.
- 检查这些变化与运动,认知和情绪症状之间的关联.
- 探索与年龄有关的影响大脑小脑功能连接在PD.
主要方法:
- 从82名患有PD (PwPD) 的参与者和38名健康对照者 (HCs) 中获得了结构性和静止状态功能性MRI扫描.
- 对小脑进行了体积测量分析.
- 分析了涉及小脑和皮层-子皮层网络的网络内部和网络间的功能连接.
主要成果:
- 在PwPD和HC之间没有发现小脑体积的显著差异.
- PwPD显示小脑网络内以及小脑 (CER) 和突出网络 (SN) 之间的功能连接性降低 (P < 0.001).
- 降低CER-SN连接与较低的认知分数 (MoCA) 和较高的抑郁症状 (HAMD) 相相关. CER - 中间叶 (MTL) 连接与焦虑 (HAMA) 和抑郁 (HAMD) 分数相关. 两组之间CER-SN连接的年龄相关差异显著 (P = 0.008).
结论:
- 在帕金森病中,小脑功能网络连接性发生变化.
- 这些变化与认知障碍和情绪障碍有关,特别是抑郁和焦虑.
- 小脑在PD的情感和认知维度中发挥着重要作用,与年龄相关的连接性修改有关.
相关概念视频
Neural Regulation
43.2K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.2K
Role of Cerebellum and Prefrontal Cortex in Memory
1.1K
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
1.1K
Parkinson's Disease: Overview
1.8K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
1.8K
Cerebellum: Anatomical Regions
4.1K
The cerebellum, also known as the "little brain," is located in the posterior cranial fossa, inferior to the tentorium cerebelli and dorsal to the brainstem. It plays a significant role in motor control, coordination, and proprioception.
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis. The...
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis. The...
4.1K
Brainstem
5.8K
The brainstem, located inferior to the brain and superior to the spinal cord, serves as a bridge between the cerebrum and the spinal cord. It plays a vital role in relaying information and controlling critical life functions. It comprises three primary regions: the midbrain, pons, and medulla oblongata.
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
5.8K
Parkinson's Disease: Treatment
995
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
995


