在精神分裂症和双相情感障碍中对白质的扩散基光谱成像
Daniel Mamah1, Aakash Patel2, ShingShiun Chen2
1Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid, Campus Box 8134, St. Louis, MO, 63110, USA. mamahd@wustl.edu.
Brain imaging and behavior
|June 6, 2025
概括
精神分裂症涉及广泛的大脑炎症和白质中纤维密度降低,与双极性障碍不同. 扩散基谱成像 (DBSI) 可以帮助识别需要早期干预的个体.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 神经炎症是一种神经炎症.
背景情况:
- 神经炎症与精神分裂症 (SCZ) 病理生理学有关.
- 对大脑炎症的体内成像工具是有限的.
- 扩散基谱成像 (DBSI) 量化了白质 (WM) 中的微观结构变化.
研究的目的:
- 使用扩散基谱成像 (DBSI) 调查精神分裂症 (SCZ) 和双相情感障碍 (BPD) 中的白质 (WM) 微观结构变化.
- 为了比较SCZ,BPD和控制 (CON) 组之间的DBSI指标.
- 探索SCZ中DBSI指标的临床相关性.
主要方法:
- 从27名CON,21名SCZ和21名BPD参与者 (年龄在18-30岁) 获得的高方向扩散MRI数据.
- 基于通道的应用空间统计 (TBSS) 用于全脑WM分析.
- 在不同组之间比较DBSI衍生的扩散量 (细胞性,受限纤维分数,外轴突水) 并与临床症状相关.
主要成果:
- 在SCZ的参与者中,DBSI衍生的细胞性 (神经炎症标志物) 增加,受限纤维分数 (轴突密度标志物) 减少,在WM通道中增加了轴突外水 (血管性胀标志物).
- BPD参与者表现出最小的WM异常,主要是在体.
- 在SCZ和CON组中,DBSI指标与精神病和情绪症状有显著的相关性.
结论:
- 精神分裂症与泛白质神经炎症,纤维密度下降和脱髓化有关.
- 这些DBSI检测到的WM异常在双相情感障碍中没有观察到.
- DBSI具有识别高风险个体的潜力,可用于早期干预,以改善结果.
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