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营养不良儿童体重增加的风险和益处
Beverly I Strassmann1,2, Claudius Vincenz2, Eduardo Villamor3
1Department of Anthropology, University of Michigan, Ann Arbor.
JAMA network open
|June 6, 2025
概括
马里的儿童体重增加与更高的成年人身高有关,肥胖或高血压的风险最小. 增加身高的好处超过了体重增加对健康的潜在负面影响.
科学领域:
- 全球健康 全球健康
- 儿科健康 儿科健康
- 营养流行病学 营养流行病学
背景情况:
- 以前在低资源环境中进行的研究将儿童体重增加与成人肥胖和高血压联系起来.
- 然而,这些研究并没有直接比较超重的风险与增加成人身高的好处.
研究的目的:
- 测试假设,从1岁到10岁的1-SD体重增加与更高的成年人身高有关,而不会增加肥胖或高血压的风险.
- 分析成年人身高和BMI在儿童体重和成年人缩血压 (SBP) 之间的关系中扮演的中介角色.
主要方法:
- 在马里进行的前性队列研究 (Dogon纵向研究) (1998-2019).
- 使用线性混合模型进行调解分析,以评估童年体重对成人SBP,身高和BMI的总,直接和间接影响.
- 参与者:F1一代儿童 (如果在1998年4月15日或2000年7月2日之前出生,年龄在5岁以下,则有资格).
主要成果:
- 儿童体重轨迹的1-SD增加与成人身高的增加有关 (女性:+3.0厘米;男性:+4.1厘米).
- 1-SD儿童体重增加对成人SBP的总影响由成人身高和BMI介导,对SBP有显著的直接影响.
- 肥胖和高血压的风险很小:1-SD体重增加与女性1.6%的肥胖患病率相关,SBP增加很小.
结论:
- 研究结果支持这一假设,表明儿童体重增加对成人高血压和肥胖的风险相比,在这个营养不良的人群中,成人身高增加的好处很小.
- 突出了早期营养,成长和长期健康结果之间的复杂相互作用.
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