基于家庭的跨直流刺激与用于纤维肌痛的安慰剂:随机临床试验
Wolnei Caumo1,2,3, Barbara Regina Franca1,2, Roman Orzechowski1,2,3
1Post-Graduate Program in Medical Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
JAMA network open
|June 6, 2025
概括
阳横直流刺激 (A-tDCS) 与运动和疼痛神经科学教育 (PNE) 结合,显著减少了纤维肌痛的疼痛和残疾. 这种方法被证明是有效的,特别是在对安慰剂测试有反应的个体中.
科学领域:
- 神经科学是一个神经科学.
- 临床试验 临床试验
- 疼痛管理 疼痛管理
背景情况:
- 之前的研究表明,在家中进行的阳横直流刺激 (A-tDCS) 可能会改善纤维肌痛症状.
- 然而,长期影响,运动和疼痛神经科学教育 (PNE) 的影响以及安慰剂的影响需要进一步研究.
研究的目的:
- 评估A-tDCS与运动和PNE相结合的疗效,与假冒的tDCS相比,减轻纤维肌痛疼痛和残疾.
- 探索安慰剂反应在治疗结果中的作用.
主要方法:
- 一个双盲,假控制的随机临床试验,涉及112名患有纤维肌痛的女性.
- 参与者接受了为期4周的家庭A-tDCS或假 tDCS,以及运动和PNE.
- 使用多维疼痛干扰指数 (MPII) 测量疼痛和残疾.
主要成果:
- 与假装tDCS组 (16.08%) 相比,A-tDCS组显示了MPII (38.76%) 的显著减少.
- 在安慰剂反应者和非反应者中,A-tDCS表现出有效性.
- 在A-tDCS组中,超过62%的参与者在MPII方面取得了50%或更大的改善.
结论:
- 当与运动和PNE相结合时,A-tDCS为控制与纤维肌痛相关的疼痛和残疾提供了显著的好处.
- 这些发现支持将A-tDCS纳入纤维肌痛治疗方案,并有助于理解神经调节疗法中的安慰剂效应.
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