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Updated: Sep 19, 2025

Assays for Validating Histone Acetyltransferase Inhibitors
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希斯脱乙酶抑制剂向在尤文肉瘤细胞中的DNA复制调节器和复制应激

Stacia L Koppenhafer1, Elizabeth L Geary1, Mary V Thomas1

  • 1Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Iowa, Iowa City, Iowa.

Cancer research communications
|June 6, 2025
PubMed
概括

基斯脱乙酶 (HDAC) 抑制剂通过减少关键蛋白质,如RRM1,RRM2,CHK1,WEE1,MCM2-7和CDT1.1,来破坏尤宁肉瘤中的DNA复制. 这损害了癌细胞复制DNA和响应复制压力的能力.

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