在多次采集时间内血液大麻素度的变化,在驾驶时受到药物影响的情况下进行案例研究
Brianna L Peterson1, Meaghan R Hessler1
1NMS Labs, Horsham, PA 19044, United States.
Journal of analytical toxicology
|June 6, 2025
概括
在驾驶障碍病例中解释大麻使用是具有挑战性的. 这项研究发现,即使采用多个血液样本,由于THC度的变化,确定大麻消费的确切时间仍然很困难.
科学领域:
- 法医毒理学 法医毒理学
- 药理动力学 药理动力学
- 毒品促成的犯罪行为
背景情况:
- Δ9-四大麻素 (THC) 是全球最常见的非法药物.
- 由于潜在的残留水平,解释在药物影响下驾驶 (DUID) 案件中的THC度是复杂的.
- 澄清大麻使用时间对于DUID案件的裁决至关重要.
研究的目的:
- 为了确定可疑DUID病例的司机在多个时间点收集的血液中的大麻素度.
- 评估大麻素度随时间的变化是否有助于确定大麻使用的时间.
- 在DUID调查中评估连续抽血的实用性.
主要方法:
- 从2019年1月到2023年12月对大麻素阳性DUID病例的分析.
- 包括多次抽血的病例 (n=35,总计81个样本).
- 液体染色学-并联质谱学 (LC-MS/MS) 用于大麻素量化 (THC,11-OH-THC,THC-COOH).
主要成果:
- THC度在0.74至40 ng/mL之间.
- 11个样本显示THC度在较晚的采集时间增加.
- 大麻素度有显著的变化,THC-COOH达到了470 ng/mL.
结论:
- 该研究强调了解释大麻使用时间表的固有困难,即使在DUID病例中采用连续血液样本.
- 在某些情况下,随着时间的推移观察到THC度的增加使时间评估复杂化.
- 需要进一步的研究,以建立可靠的生物标志物,用于最近的大麻消费在法医背景下.
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