在艾滋病毒感染者中探索PREVENT HF得分和心肌功能
Allie R Walpert1, Mansi Gupta1, Carolyn N Dunderdale1
1Metabolism Unit.
AIDS (London, England)
|June 6, 2025
概括
AHA PREVENT HF得分与艾滋病毒 (PWH) 患者的心磁共振成像发现相关,这些人患有亚临床心肌功能障碍. 这表明得分可能有助于识别PWH的早期心脏病风险.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 医疗成像医学成像
背景情况:
- 艾滋病毒感染者 (PWH) 患心肌结构变化的风险增加,可能导致心力衰竭与保留射出分数 (HFpEF).
- 早期发现亚临床心肌功能障碍对于管理PWH中心血管疾病 (CVD) 风险至关重要.
- AHA PREVENT HF风险评分是预测心血管事件的工具,但其在亚临床疾病的PWH中的实用性需要研究.
研究的目的:
- 探索艾滋病毒 (PWH) 感染者的AHA PREVENT HF风险评分和心磁共振 (CMR) 影像检测结果之间的关联.
- 评估PREVENT HF得分与PWH中亚临床心肌功能障碍和炎症指标的相关性.
主要方法:
- 一项涉及37名接受抗逆转录病毒治疗 (ART) 的PWH,年龄在40-65岁之间,没有已知的心血管疾病的横截面研究.
- 参与者接受了心脏磁共振 (CMR) 成像.
- 计算了AHA PREVENT HF风险评分,并与CMR衍生的测量结果相关联,包括左心室体积指数 (LAVI),全球纵向应变 (GLS),左心室质量指数 (LVMI),细胞外体积 (ECV) 和T1放松时间.
主要成果:
- PREVENT HF得分与LAVI (ρ=0.35,P=0.04),T1放松时间 (ρ=0.35,P=0.04),介质素-6 (IL-6) (ρ=0.36,P=0.03) 和NT-proBNP (ρ=0.42,P=0.01) 有显著的相关性.
- 在满足LAVI (>34毫升/米2) 和T1放松时间 (≥1250毫秒) 的临床切线的个体中观察到更高的风险得分.
- 为预测升高的LAVI (2.5,AUROC 0.769) 和T1放松时间 (3.6,AUROC 0.727) 确定了PREVENT HF得分的最佳切线.
结论:
- AHA PREVENT HF得分与非临床疾病的无症状PWH中心肌结构和炎症变化的指标有关.
- 这些发现表明,PREVENT HF评分在评估与PWH心脏健康相关的放射性发现时具有潜在的实用性.
- 需要进一步的研究来验证PREVENT HF得分作为PWH人群中心血管结果的预测工具.
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