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Updated: Sep 19, 2025

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
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In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol

Published on: December 30, 2016

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诱导性蛋白质降解揭示了Treg细胞谱系定义转录因子Foxp3的炎症依赖功能

Christina Jäger1,2, Polina Dimitrova1,2, Qiong Sun1

  • 1Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Campus-Vienna-Biocenter 1, A-1030 Vienna, Austria.

Science immunology
|June 6, 2025
PubMed
概括

调节性T (Treg) 细胞维持免疫平衡. 这项研究表明,Treg细胞可以在没有Foxp3蛋白质的情况下运行数天,但炎症会触发它们的选择性损失,影响自身免疫和癌症免疫力.

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