对精神病参与者临床高风险的重叠结构和功能连接性障碍:网络分析研究
Angus Paton1, Tineke Grent- 't-Jong2, Ruchika Gajwani3
1Institute for Neuroscience and Psychology, Univ. of Glasgow, UK.
NeuroImage. Clinical
|June 6, 2025
概括
临床高危精神病 (CHR-P) 参与者在结构性和功能性网络中表现出广泛的脑连接障碍. 这些变化与症状严重程度相关,并可能预测临床结果.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 精神分裂症与异常的大脑网络连接有关.
- 目前尚不清楚这些干扰是否存在于临床高危精神病 (CHR-P) 个体中,以及结构和功能连接性改变是否重叠.
研究的目的:
- 与健康对照组 (HC) 相比,研究CHR-P参与者的结构和功能大脑连接差异.
- 探索CHR-P的结构和功能连接变化之间的重叠.
- 检查连接性,临床症状,认知功能和临床结果之间的相关性.
主要方法:
- 获得的扩散MRI (dMRI) 和静止状态fMRI (rsfMRI) 数据来自110名CHR-P参与者和49名HC.
- 使用网络分析来比较dMRI和rsfMRI连接,并识别重叠.
- 与临床和神经认知变量和结果相关联的连接数据.
主要成果:
- 在dMRI和rsfMRI中,CHR-P参与者表现出头,头,头和额叶皮层的超高和低连接性.
- 在视觉,右腹注意力和右默认模式网络中发现了CHR-P和HC之间的重叠连接差异.
- 连接性改变与症状严重程度和认知缺陷有显著的相关性.
- 与非持久性CHR-P个体相比,持久性CHR-P个体显示出不同的连接模式.
结论:
- 在CHR-P参与者中存在微妙但广泛的dMRI和rsfMRI连接中断.
- 特定的大脑区域 (头,头,头,额头) 显示出与临床和认知障碍相关的连接性改变.
- dMRI和rsfMRI连接性测量可以作为潜在的生物标志物,用于预测CHR-P的临床结果.
相关概念视频
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
1.0K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
1.0K
Psychological and Sociocultural Causes of Schizophrenia
208
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
208
Biological Causes of Schizophrenia
156
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
156


