开发和表征α-酸无形固体分散剂,以改善口服生物可用性和调节过敏气道炎症
Ruchika1, Navneet Thakur2, Narendra Vijay Tirpude1
1Dietetics and Nutrition Technology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh 176061, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Colloids and surfaces. B, Biointerfaces
|June 6, 2025
概括
这项研究开发了使用Soluplus的α-酸固体分散剂 (LASD),以提高口服生物可用性. 拉斯德有效地减少了过敏性气道炎症,显示了改善治疗应用的前景.
科学领域:
- 药理学和制药科学 药理学和制药科学
- 免疫学 免疫学 免疫学
- 材料科学 材料科学 材料科学
背景情况:
- 阿尔法-酸 (LA) 是一种具有有限生物可用性的天然抗氧化剂,阻碍了其临床使用.
- 由卵泡脂聚糖 (OVA-LPS) 诱导的过敏呼吸道炎症是一个重要的治疗挑战.
- 提高LA的口服输送和疗效对于其治疗潜力至关重要.
研究的目的:
- 开发和描述使用Soluplus (SOL) 的α-酸固体分散剂 (LASD).
- 提高LA在过敏气道炎症的口服生物可用性和治疗疗效.
- 在OVA-LPS诱导的小鼠模型中研究LASD的抗炎作用.
主要方法:
- 通过冷化和优化进行LASD制备.
- 使用FT-IR,DSC,TGA和P-XRD进行固态表征.
- 在体外溶解,药理动力学研究,以及对炎症标志物和肺组织病理学的评估 in vivo.
主要成果:
- 鉴定证实了SOL矩阵中的LA的分子分散和无形转化.
- 与本地LA相比,LASD显示口服生物利用率增加了5.3倍,并增强了体外溶解.
- 拉斯德显著降低了呼吸道炎症,细胞因子水平,炎症标志物和肺组织损伤.
结论:
- 拉斯德配方有效地克服了原生阿尔法-酸的生物可用性和治疗限制.
- 这种方法为管理过敏气道炎症提供了一个有希望的策略.
- 开发的LASD有可能改善阿尔法-酸的临床应用.
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