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Updated: May 3, 2026

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发现了一种ALK降解剂,用于拉提尼布耐药化合物突变

Fei Gao1, Zhenhua Wu1, Anqi Lin2

  • 1State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, 361102, China; State-province Joint Engineering Laboratory of Targeted Drugs from Natural Products, Xiamen University, Xiamen, 361102, China; Cancer Research Center of Xiamen University, Xiamen, 361102, China.

European journal of medicinal chemistry
|June 6, 2025
PubMed
概括

一种新的ALK抑制剂WZH-15-125及其PROTAC衍生物WZH-17-002克服了ALK阳性非小细胞肺癌的耐药性. WZH-17-002有效降解ALK蛋白,并在临床前模型中显示出优异的疗效.

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