直接的酒精生物标志物和酒精自我报告之间的强烈一致性和相关性在年轻人中具有可变的饮酒模式
Lindsay R Meredith1, Anna E Kirkland1, ReJoyce Green1
1Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.
Drug and alcohol dependence
|June 6, 2025
概括
像EtG和PEth这样的酒精生物标志物与青少年自我报告的饮酒情况有很好的一致性. 在初次访问时收集生物标志物可以帮助确定青少年酒精研究的研究资格.
科学领域:
- 青少年健康 青少年健康
- 生物标志物 生物标志物
- 药物使用研究研究 药物使用研究
背景情况:
- 青少年过度饮酒会带来严重的后果,但往往没有被发现.
- 青少年使用酒精的自我报告措施可能由于回忆偏差和报告不足而不可靠.
- 客观生物标志物可以提供更准确的评估青少年的酒精消费和相关问题.
研究的目的:
- 评估客观酒精生物标志物 (EtG,PEth) 与青少年自我报告的饮酒之间的一致性.
- 探索PEth在预测与酒精有关的严重性结果中的实用性.
- 在研究环境中评估生物标志物的有效性,以确定青少年饮酒模式.
主要方法:
- 青少年 (15-19岁) 饮酒模式很少或很重,在两次访问中提供了自我报告和生物样本.
- 尿液中乙糖化物 (EtG) 和全血酸乙醇 (PEth) 的量化.
- 统计分析,包括科恩的卡帕和斯皮尔曼相关性,比较生物标志物水平与自我报告的酒精消费.
主要成果:
- EtG与最近的饮酒有中度至实质性的一致性,随着时间的推移而有所改善.
- PEth与饮酒有很大的一致性,与饮酒量有很强的相关性.
- 虽然两种生物标志物都没有一致预测严重性结果,但PEth提高了某些结果的模型准确性.
结论:
- 酒精生物标志物 (EtG,PEth) 通常与青少年在研究环境中自我报告的饮酒情况一致.
- 在初次预约时收集酒精生物标志物可以告知研究资格.
- 仅仅是酒精消费量并不能完全解释青少年报告的与酒精有关的后果.
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