用多巴胺激动剂治疗的前乳腺瘤患者的冲动控制障碍:系统性审查和分析与试验顺序分析
Plamen Penchev1, Daniela Milanova-Ilieva2, Lyubomir Gaydarski3
1Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria.
概括
多巴胺激动剂 (DAs) 可能会增加冲动控制障碍 (ICD) 风险在前乳腺瘤患者,特别是高性欲和权衡. 在DA治疗期间建议进行ICD的常规查.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 多巴胺激动剂 (DAs) 是对益生菌瘤的主要治疗方法.
- 长期使用DA与精神病并发症有关,包括冲动控制障碍 (ICD).
- 关于与帕金森病患者相比,益生菌瘤患者的ICD患病率的数据有限.
研究的目的:
- 系统地审查和元分析用DA治疗的益生菌瘤患者中ICD的患病率.
- 在这个人群中识别与DA治疗相关的特定ICD.
- 为临床实践提供有关监测和查的信息.
主要方法:
- 在PubMed,Cochrane和Scopus数据库中进行系统搜索.
- 包括8项研究,包括858名患者,其中483人接受DA治疗.
- 随机效应模型的元分析使用R 4.3.1和RevMan 5.4.1.1.
主要成果:
- DA治疗与更高的ICD患病率有关 (RR 1.71;p=0.0002).
- 高性欲 (RR 2.61; p=0.0001) 和评价 (RR 2.31; p=0.003) 与DA使用有显著的关联.
- 高性欲在男性中更为普遍;对于博,过度饮食或强迫性购物没有显著差异.
结论:
- 多巴胺激动剂可能会增加ICDs的风险,特别是高性欲和反,在前乳腺瘤患者.
- 在治疗益生菌瘤的多巴胺激动剂治疗期间,对ICD进行例行查是有必要的.
- 由于所包含的研究的观察性质,研究结果应谨慎解释.
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