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系统性氧化应激与老年人群中妄有关,部骨折
Monika Trzpis1, Maria Zernova2, Karin M Vermeulen2
1Department of Internal Medicine, The University Center for Geriatric Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Alzheimer Centrum Groningen, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Experimental gerontology
|June 6, 2025
概括
减少的自由硫醇,表明系统性氧化应激,与老年骨折患者的妄想有关. 这一发现突出了在手术患者中妄风险评估的潜在生物标志物.
科学领域:
- 老年医学 老年医学
- 手术并发症 手术并发症
- 生物化学 生物化学
背景情况:
- 氧化压力与部骨折手术后的妄想病理生理学有关.
- 循环的自由硫醇 (R-SH) 是系统性氧化应激的生物标志物.
- 在部骨折患者中,研究 Delirium 和氧化应激之间的联系至关重要.
研究的目的:
- 检查患有骨骨折住院的老年患者中 Delirium 和全身氧化应激之间的关系.
- 为了确定减少的自由硫醇度是否与妄想发病率相关.
主要方法:
- 分析了来自336名65岁以上因关节骨折住院的患者的813个血样本.
- 根据DSM-IV标准进行 Delirium 诊断.
- 使用色度检测测对素调整后的血自由硫醇度的纵向测量.
主要成果:
- 在33%的患者 (110分之336) 中发生了 Delirium.
- 与非狂妄症患者 (7.5μM/g) 相比,患有狂妄症的患者具有较低的白素调整后自由硫醇度 (7.3μM/g) 的平均值.
- 多变量分析显示,妄和自由硫醇水平之间存在反向关联 (OR=0.8,95%CI 0.75-0.96).
结论:
- 减少的自由硫醇度,表明系统氧化应激增加,与部骨折患者的妄想有关.
- 自由硫醇可以作为预测这种患者群体妄风险的潜在生物标志物.
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