新型血栓标志物的诊断价值在COPD中具有深静脉血栓症
Jiajun Huang1, Jie Huang2, Chunli Sun2
1School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, Guangdong, PR China.
The American journal of the medical sciences
|June 6, 2025
概括
新的血栓形成标志物,如血栓抗血栓复合物 (TAT) 和血栓模块素 (TM),在慢性阻塞性肺病 (COPD) 患者中预测深静脉血栓 (DVT) 的诊断价值.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 血液学 血液学 血液学
背景情况:
- 慢性阻塞性肺病 (COPD) 患者患深静脉血栓症 (DVT) 的风险增加.
- 对于COPD中DVT的准确诊断标记对于及时干预至关重要.
- 传统的标志物可能无法完全捕捉该人群中的血栓形成风险.
研究的目的:
- 评估新型血栓形成标志物对COPD患者内心深血管发生率的诊断效用.
- 为了比较血栓抗血栓复合物 (TAT),等离子素-α2-等离子素抑制剂复合物 (PIC),血栓模块素 (TM) 和组织等离子素激活剂-抑制剂复合物 (t-PAIC) 的疗效.
主要方法:
- 分析了98名COPD患者和50名健康对照者的队列.
- 患者被分为非DVT和DVT组.
- 测量了血糖,脂质概况和新型血栓形成标志物;采用了ROC曲线分析.
主要成果:
- 两组之间没有观察到葡萄糖或脂质配置文件的显著差异.
- 纤维素降解产物 (FDP) 和D-二聚物 (D-D) 在DVT组中升高.
- 在患有DVT的COPD患者中,TAT,PIC,TM和t-PAIC水平显著更高. 结合TAT和TM显示出高的诊断疗效 (AUC为0.833,灵敏度为87.5%).
结论:
- 血清中TAT,PIC,TM和t-PAIC的水平是COPD患者中DVT的有价值的诊断指标.
- TAT和TM的组合提供了卓越的诊断性能.
- 这些标志物可以帮助在这个高危人群中早期发现和治疗DVT.
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