在TriNetX数据库中,梅毒性膜炎和相关的眼部并发症的发病率和流行率
Lucy R Zhou1, Nila Kirupaharan1, Meghan K Berkenstock2
1From the Drexel University College of Medicine (L.R.Z., N.K.), Philadelphia, PA.
American journal of ophthalmology
|June 6, 2025
概括
梅毒性脑膜炎的发病率在美国正在上升,反映了梅毒流行病. 早期诊断和治疗对于预防这种眼部并发症导致的视力丧失至关重要.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 梅毒是一种全身性感染,具有潜在的眼部表现.
- 梅毒性脑膜炎,是由于梅毒而引起的脑膜炎症,可能导致严重的视力障碍.
- 了解梅毒性脑膜炎的流行病学对于及时诊断和管理至关重要.
研究的目的:
- 为了确定每年和累积发生率和梅毒性脑膜炎的患病率.
- 在患有梅毒性脑膜炎的患者中识别并发性传播感染 (STIs) 和眼部并发症.
- 用美国TrinetX数据库从2013年到2024年分析梅毒性脑膜炎的趋势.
主要方法:
- 使用TriNetX数据库进行了一项趋势研究.
- 确定了在一个月内被诊断患有脑膜炎和阳性梅毒测试 (三角膜和非三角膜) 的患者.
- 收集和分析了人口统计,同时感染 (艾滋病毒,淋病,克拉米迪亚) 和眼部并发症 (黄斑,低视力) 的数据.
主要成果:
- 该研究在超过8100万个人中发现了237例梅毒性脑膜炎病例.
- 梅毒性脑膜炎的累积发病率和流行率分别为每10万人口中的0.36和0.27.
- 艾滋病毒是最常见的共同感染 (32.49%),低视力/失明是最常见的眼部并发症 (27.85%).
结论:
- 梅毒性脑膜炎的发病率和患病率的增加与美国更广泛的梅毒流行病相关.
- 常规的梅毒血清检测是推给患者呈现的脑膜炎.
- 迅速干预至关重要,以防止与梅毒性脑膜炎相关的不可逆转的视力损伤.
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