双相情绪障碍患者治疗前和治疗后的神经成像变化及其与遗传特征的关系
Chunguo Zhang1, Jiaquan Liang1, Haohao Yan2
1Department of Psychiatry, The Third People's Hospital of Foshan, Foshan, Guangdong 528000, China.
Journal of affective disorders
|June 6, 2025
概括
双极性障碍 (BD) 患者在 Salience Network (SN) 和 Dorsal Attention Network (DAN) 中显示出大脑功能连接 (FC) 的改变. 治疗后的SN FC变化可能表明有效性,具有与突触过程的遗传联系.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
背景情况:
- 双极性障碍 (BD) 与大脑活动的显著改变有关.
- 了解治疗前后大脑功能连接 (FC) 的变化对于BD管理至关重要.
- 研究神经影像同质性,异质性和遗传变异,为BD病理生理学提供了洞察力.
研究的目的:
- 在双相情感障碍 (BD) 患者的 Salience Network (SN) 和 Dorsal Attention Network (DAN) 中探索大脑功能连接 (FC) 的变化.
- 在BD患者治疗前后检查FC变化.
- 调查神经影像同质性,异质性和与BD中FC变化相关的遗传关联.
主要方法:
- 在 Salience 网络 (SN) 和 Dorsal Attention 网络 (DAN) 中分析基于种子和全脑功能连接 (FC).
- 包括83名健康对照 (HC) 和77名BD患者,其中38人完成了随访.
- 检查遗传关联与神经成像发现在BD.
主要成果:
- 与HC相比,BD患者在SN和DAN中表现出异常的基线FC.
- 在处理后,SN FC在某些地区下降,而DAN FC保持不变.
- 鉴定了与 BD 中的 FC 变化相关的基因,在突触传输和离子运输通路中得到丰富.
结论:
- 突出网络 (SN) 功能连接 (FC) 的变化可以作为神经影像标记,用于治疗双相情感障碍 (BD) 的疗效.
- 基因神经成像关联分析提供了对BD中FC变化的基础分子机制的全面了解.
- 这些发现突显了SN FC作为BD治疗响应生物标志物的潜力.
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