基于德克斯的双动态网络水凝用于慢性伤口愈合,具有机械适应性,抗菌性和pH响应性药物输送
Jinyuan Geng1, Guowei Zhou2, Song Guo2
1State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211800, PR China.
International journal of biological macromolecules
|June 6, 2025
概括
一种新的双动态网络水凝为慢性伤口提供了一种灵活的,可以控制感染的解决方案. 这种先进的伤口带显示出卓越的机械性能和响应性药物输送,以获得更好的愈合结果.
科学领域:
- 生物材料科学 生物材料科学
- 伤口治愈研究研究 伤口治愈研究
- 药物输送系统 药物输送系统
背景情况:
- 慢性不愈合的伤口由于当前包装技术的局限性而构成重大临床挑战.
- 现有的伤口护理选择往往缺乏必要的灵活性,感染控制和响应性治疗交付能力.
研究的目的:
- 开发一种新的双动态网络水凝,用于慢性伤口治疗,具有增强的性能.
- 创建一个多功能伤口带,它结合了机械强度,抗菌活性和受控的药物释放.
主要方法:
- 通过共价希夫基键和Al3+-carboxyl协调,通过氧化德克斯 (ODex),聚乙烯胺修饰凝 (PEI-Gel),聚烯酸 (PAA) 和离子 (Al3+) 合成了水凝.
- 在各种应力条件下评估水凝的机械性能,包括延伸能力和拉伸强度.
- 在体外对常见伤口病原体的抗菌有效性进行了评估,并量化了pH响应的药物释放动力学.
主要成果:
- 开发的水凝 (DPA) 显示出优异的类似组织的可变性 (920.9 ± 1.2%延长) 和显著的抗拉强度 (0.54 ± 0.3 MPa).
- 具有强烈的抗菌活性,具有较低的最低抑制度 (MIC90) 值,可以对抗大肠杆菌,白杆菌和S. saprophyticus.
- 展示了对pH响应的药物释放特征,在pH值3.0时168小时内达到90%以上的emodin释放.
结论:
- 双动态网络水凝为慢性皮肤伤口管理提供了一个有前途的平台.
- 它的优越机械特性,结合抗菌特性和智能药物输送,解决尚未满足的临床需求.
- 这种创新的水凝有可能促进伤口护理疗法的发展.
相关概念视频
01:19Modified-Release Drug Delivery Systems: Rate-Programmed II
137
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
137
01:22Modified-Release Drug Delivery Systems: Rate-Programmed I
172
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
172
01:30Modified-Release Drug Delivery Systems: Stimuli-Activated
177
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
177
01:11Oral Drug Delivery Systems: Delayed-Release Systems
222
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
222
01:18Transdermal Drug Delivery Systems
233
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
233