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Updated: Sep 13, 2026

A Robust Polymerase Chain Reaction-based Assay for Quantifying Cytosine-guanine-guanine Trinucleotide Repeats in Fragile X Mental Retardation-1 Gene
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A Robust Polymerase Chain Reaction-based Assay for Quantifying Cytosine-guanine-guanine Trinucleotide Repeats in Fragile X Mental Retardation-1 Gene

Published on: September 16, 2019

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治疗性FMRP-N-tat的互动组揭示了脆弱X神经元中细胞功能的关键相互作用

Kévin Leguay1, Mariana Acevedo1, Eva Colic1

  • 1Department of Pharmacology, adMare BioInnovations, Montréal, Quebec, Canada.

The Journal of biological chemistry
|June 6, 2025
PubMed
概括

脆弱X综合征 (FXS) 缺乏改变疾病的治疗方法. 一个新的FMRP N-tat片段通过与关键细胞蛋白相互作用来恢复FMRP缺陷细胞的功能,显示了潜在的潜力.

关键词:
在FMRP中使用FMRP.脆弱的X综合征是什么?细胞透的.质谱测量质谱测量质谱测量质谱测量质量测量质谱测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量的相互作用 相互作用

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Regulation of the Unfolded Protein Response01:31

Regulation of the Unfolded Protein Response

Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...