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先进的微生物组疗法通过恢复肠道微生物群平衡和小鼠模型中的肠肝轴来加速MASLD恢复

Johnson Lok¹, Congjia Chen², Valeria Iannone¹

¹School of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio 70210, Finland.

Journal of agricultural and food chemistry

|June 6, 2025

概括

先进的微生物组疗法, EcNI 和 EcNA,在治疗与代谢功能障碍相关的脂肪性肝病 (MASLD) 中表现有前途. 这些疗法改善了小鼠的肝脏健康和肠道平衡,表明了潜在的新疗法选择.

科学领域:

微生物学微生物学
肝病学肝病学是一种肝病学.
代谢疾病代谢疾病

背景情况:

肠道微生物群失调和内分泌干扰是代谢功能障碍相关的脂肪性肝病 (MASLD) 发病的核心.
恢复肠肝轴平衡对于MASLD恢复至关重要.

研究的目的:

调查先进微生物组疗法在MASLD恢复期间恢复肠道微生物平衡和肠肝轴平衡方面的有效性.
评估工程 * Escherichia coli * 尼斯尔 1917 菌株 (EcNI 和 EcNA) 作为潜在的 MASLD 治疗方法.

主要方法:

在小鼠中,MASLD通过高脂肪,高糖饮食诱导,然后进行标准饮食干预.
干预组接受了经过工程设计的 *E. coli* Nissle 1917 表达IGF1 (EcNI) 或阿尔达费林 (EcNA).
对照组接受了*大肠杆菌*尼斯尔1917载体 (EcN) 或没有干预 (CTRL).

主要成果:

埃克尼和埃克纳显著改善了MASLD的恢复,减少了肝脏脂肪,血胆固醇和体重.
治疗增加了细菌多样性,血酸和酸,表明改善了肠道微生物平衡.
代谢途径被调节,降低了乙-CoA和类固醇激素生物合成的调节,并提高了与氧化应激减轻相关的途径的调节.

结论:

工程 *大肠杆菌* 尼斯尔 1917 菌株 (EcNI 和 EcNA) 显示出作为 MASLD 新型治疗剂的潜力.
这些基于微生物组的干预措施可以恢复肠肝轴的平衡,并缓解MASLD的关键方面.
对ecni和ecna的进一步研究可能会导致肝脏疾病的新治疗策略.

关键词:

大肠杆菌尼斯尔 1917 年这就是Aldafermin.纤维细胞生长因子 19 类似胰岛素的生长因子1 整合性的多元经济学.非酒精性脂肪性肝病 (NAFLD) 是一种非酒精性脂肪性肝病.

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