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非侵入性减少神经硬性改变了人类自闭症行为
Takamitsu Watanabe1, Hidenori Yamasue2
1International Research Center for Neurointelligence, The University of Tokyo Institutes for Advanced Study, Tokyo, Japan. takamitsu-watanabe@g.ecc.u-tokyo.ac.jp.
Nature neuroscience
|June 6, 2025
概括
跨磁刺激 (TMS) 降低了自闭症成年人的大脑刚性,从而改善了社会和非社会自闭症行为. 这种干预增强了神经灵活性,积极影响了认知不灵活性和沟通.
科学领域:
- 神经科学是一个神经科学.
- 自闭症研究 自闭症研究
- 大脑动力学 大脑动力学
背景情况:
- 自闭症行为与刚性神经动力学有关.
- 改变这些刚性大脑动态可能会改变自闭症特征.
研究的目的:
- 调查依赖状态的跨脑磁性刺激 (TMS) 对自闭症成年人的神经刚性的行为影响.
- 确定降低神经刚性是否可以改变自闭症特征.
主要方法:
- 在自闭症成年人中利用了依赖状态的横磁性刺激 (TMS),以右头顶叶片为目标.
- 评估了干预后的纵向行为变化和神经动态.
主要成果:
- 刺激性TMS在右顶叶片上降低了神经刚性,相应地减少了社会和非社会自闭症行为.
- 经TMS诱导的神经灵活性导致认知不灵活性立即下降,感知过度稳定性和非典型非语言沟通的缓慢减少.
- 增强的网络合 (面对面-视觉,面对面-默认模式-突出) 与特定的行为改善相关.
结论:
- 通过TMS改变神经刚性可以修改多个自闭症特征.
- 针对神经动态提供了治疗性干预自闭症谱系障碍的潜在途径.
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