针对儿童自闭症谱系障碍的潜在肠脑轴向疗法:机遇和挑战
Min Kyung Shin1,2, Yejun Son3, Dong Keon Yon4,5,6
1Department of Medicine, Wonkwang University College of Medicine, Iksan, South Korea.
World journal of pediatrics : WJP
|June 6, 2025
概括
微生物群移植 (MT) 在患有自闭症谱系障碍 (ASD) 症状的儿童中显示出最一致的改善. 其他肠-大脑轴疗法,如益生菌和饮食,提供了可变的好处,突出了对标准化研究和个性化方法的需求.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 儿科 儿科 儿科
背景情况:
- 自闭症谱系障碍 (ASD) 缺乏确定的治疗方法.
- 新兴研究强调肠-大脑轴是儿童自闭症症状管理的治疗目标.
- 目前正在研究以肠-大脑轴为目标的疗法,包括微生物种移植 (MT),益生菌,饮食干预和营养补充剂.
研究的目的:
- 评估微生物种移植 (MT),益生菌,饮食干预和营养补充剂对儿童ASD症状的影响.
- 系统地审查关于小儿ASD肠-大脑轴向治疗的现有研究.
主要方法:
- 对2024年6月之前发表的研究进行了系统审查.
- 搜索的数据库包括PubMed/MEDLINE,Scopus和科学网.
- 纳入标准侧重于同行评审的文章,观察性研究,干预性试验,儿科自闭症患者 (18岁以下) 和最低样本大小为20人.
主要成果:
- 在3424项确定的研究中,有31项符合纳入标准.
- 微生物群移植 (MT) 在多个ASD症状领域中表现出最一致的有效性,特别是在那些有严重胃肠道问题的患者中.
- 益生菌显示了菌株特定的有效性,但不一致的行为改善. 饮食干预措施 (例如,无质无素) 和营养补充剂产生了混合和可变的结果,在饮食方面发现了坚持挑战.
结论:
- 肠-大脑轴疗法具有显著的潜力,可以改善ASD儿童及其家人的生活质量.
- 随着益生菌,饮食变化和补充剂提供额外的,尽管变化的好处,MT成为最有效的干预措施.
- 研究方案的标准化,长期研究以及具有成本效益的个性化方法对于推进这些疗法至关重要.
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