工程纳米材料在低和亚毒性暴露水平的不良反应:当前的理解和未来的前景
1Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Nanotoxicology
|June 7, 2025
概括
消费品中的工程纳米材料 (ENM) 存在风险. 研究表明,低水平的慢性ENM暴露可能会导致不良健康影响,突出显示需要新的风险评估方法.
科学领域:
- 纳米毒理学研究
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 工程纳米材料 (ENM) 越来越多地用于消费产品,因此需要彻底了解它们对人类健康的长期风险.
- 纳米毒理学已经进步,基于物理化学性质和纳米生物相互作用,改善了对ENM毒性的知识,这对于风险评估和治疗开发都至关重要.
- 当前的研究往往忽略了对低和亚毒性ENM暴露水平,慢性暴露或共同暴露的不良反应,这些更代表真实世界的场景.
研究的目的:
- 审查目前关于工程纳米材料 (ENM) 暴露在低和亚毒水平的不利健康后果的文献.
- 突出新出现的关于超越传统高剂量毒理终点的ENM暴露影响的发现.
- 讨论纳米毒理学的挑战和未来的研究方向,特别是关于慢性和低剂量暴露.
主要方法:
- 关于工程纳米材料 (ENM) 毒性的现有研究的文献综述.
- 分析着重于低和亚毒性暴露水平和慢性暴露场景的研究.
- 综合与纳米生物相互作用和不良健康结果相关的发现.
主要成果:
- 新出现的证据表明,慢性,低水平暴露于工程纳米材料 (ENM) 可能导致不良健康结果,即使没有明显的毒性.
- 暴露于ENM可能会加剧现有的共同疾病和共同毒性,强调传统高剂量毒理学评估的局限性.
- 即使在亚毒性暴露水平下也观察到不良影响,这表明需要重新评估当前的风险评估范式.
结论:
- 有必要评估工程纳米材料 (ENM) 诱导的低和亚毒性暴露水平的不良反应,反映现实世界的条件.
- 未来的研究应该集中在慢性暴露,共同暴露和非传统的毒理学终点上,以准确评估ENM的健康风险.
- 了解相关暴露水平的纳米生物相互作用对于减轻健康风险和推进纳米医学至关重要.
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