乳酸细菌抗氧化活性的评估和机制
Yuyang Xiao1, Jian Yang2, Xupeng Zhang1
1Xiangya School of Medicine, Central South University, Changsha, Hunan Province, 410013, China.
Folia microbiologica
|June 7, 2025
概括
乳酸细菌 (LAB) 通过激活细胞防御通路并产生有益的代谢物,表现出显著的抗氧化作用. 对LAB的进一步研究有望在功能性食品和制药中应对氧化应激的新型应用.
科学领域:
- 微生物学 微生物学
- 生物化学 生物化学
- 营养科学 营养科学
背景情况:
- 乳酸细菌 (LAB) 以其益生菌性质和各种健康益处而闻名.
- 氧化应激与各种健康障碍有关,需要有效的抗氧化剂策略.
研究的目的:
- 审查评估LABs抗氧化活性的方法.
- 阐明LABs多方面的抗氧化机制和作用.
主要方法:
- 在体外化学评估方法.
- 细胞模型评估方法.
- 在体内评估方法.
主要成果:
- LABs激活抗氧化剂信号通路并诱导抗氧化酶.
- LABs形成ROS结合系统,产生抗氧化代谢物,并增强肠道屏障的完整性.
- 实验室支持氧化损伤修复系统,维护线粒体功能.
结论:
- LABs具有各种抗氧化作用,对于对抗氧化应激至关重要.
- 未来的研究应该利用多学科,基因工程和临床试验来探索LAB应用.
- 研究结果支持开发基于LAB的功能性食品,药品和化品.
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