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Updated: Sep 19, 2025

Macrophage Differentiation and Polarization into an M2-Like Phenotype using a Human Monocyte-Like THP-1 Leukemia Cell Line
06:38

Macrophage Differentiation and Polarization into an M2-Like Phenotype using a Human Monocyte-Like THP-1 Leukemia Cell Line

Published on: August 2, 2021

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在HCC中,FCGR2A通过IL-4/JAK/STAT6轴促进M2巨细胞的两极分化

Shaojun Li1, Wanbo Shen2, Tingdong Yu2

  • 1Hepatobiliary Pancreatic Surgery, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Peking University Cancer Hospital Yunnan, Kunming, PR China; Hospital of Honghe State Affiliated to Kunming Medical University, Honghe, Yunnan, PR China.

Translational oncology
|June 7, 2025
PubMed
概括

这项研究确定FCGR2A是肝细胞癌 (HCC) 发展的关键驱动因素. 在M2巨细胞中高FCGR2A表达促进瘤生长和免疫抑制,这表明肝癌的新治疗点.

关键词:
在FCGR2A中,它是FCGR2A.在IL-4/JAK/STAT6轴上巨细胞的两极分化单细胞测序是一种单细胞测序.

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