环境电子穿机通过依赖生物活动的机制影响纳米生物相互作用
Kai Yang1, Wanqin Dai2, Yun Wang2
1State Key Laboratory of Clean and Efficient Coal Utilization, Taiyuan University of Technology, Taiyuan 033024, Shanxi, PR China.
Aquatic toxicology (Amsterdam, Netherlands)
|June 7, 2025
概括
梅纳 (MD) 通过增强NP溶解和重金属释放,显著增加了氧化纳米颗粒 (CeO2 NP) 对大肠杆菌 (E. coli) 的毒性. 环境分子可以改变纳米生物相互作用和毒性.
科学领域:
- 环境纳米毒理学
- 纳米生物技术纳米生物技术
- 微生物学 微生物学
背景情况:
- 纳米生物相互作用是复杂的,受到纳米粒子 (NP),生物和环境分子的影响.
- 在NP上形成生态冠状病毒是一个关键的重点,但环境分子也可以直接调节纳米-生物相互作用.
- 了解这些相互作用对于环境风险评估至关重要.
研究的目的:
- 调查环境分子梅纳 (MD) 对菌纳米颗粒 (CeO2 NPs) 对大肠杆菌 (E. coli) 的毒性的影响.
- 阐明MD影响CeO2 NP行为和毒性的机制.
- 评估环境分子在调节纳米-生物相互作用中的作用.
主要方法:
- 大肠杆菌暴露于不同度 (10,20,50毫克/升) 的CeO2NP,含有或不含有0.1毫米的MD.
- 对细菌表面CeO2NP溶解的分析.
- 测量ATP消耗和氧化应激作为毒性指标.
主要成果:
- MD显著增加了E. coli表面上的CeO2 NP溶解.
- MD充当了电子穿器,促进了CeO2 NP的减少和随后的Ce3+离子释放.
- 这导致了剂量依赖的CeO2 NP毒性恶化,由增加的ATP耗尽和氧化应激所证明.
- 仅仅MD对大肠杆菌的毒性是最小的.
结论:
- 像MD这样的环境分子可以深刻地改变纳米生物相互作用和毒性.
- 通过增加溶解和重金属离子释放,MD增强了CeO2 NP的毒性,影响了细菌细胞功能.
- 这项研究强调了纳米毒理学评估中考虑环境因素的重要性.
更多相关视频
10:23Characterizing Mediated Extracellular Electron Transfer in Lactic Acid Bacteria with a Three-Electrode, Two-Chamber Bioelectrochemical System
Published on: August 23, 2024
1.1K
10:44Translating Extracellular Electron Transfer Activities with Organic Electrochemical Transistors
Published on: January 31, 2025
825
相关概念视频
The Electron Transport Chain
17.3K
The electron transport chain or oxidative phosphorylation is an exothermic process in which free energy released during electron transfer reactions is coupled to ATP synthesis. This process is a significant source of energy in aerobic cells, and therefore inhibitors of the electron transport chain can be detrimental to the cell's metabolic processes.
Inhibitors of the electron transport chain
Rotenone, a widely used pesticide, prevents electron transfer from Fe-S cluster to ubiquinone or Q...
Inhibitors of the electron transport chain
Rotenone, a widely used pesticide, prevents electron transfer from Fe-S cluster to ubiquinone or Q...
17.3K
Oxidation and Reduction of Organic Molecules
7.8K
Energy production within a cell involves many coordinated chemical pathways. Most of these pathways are combinations of oxidation and reduction reactions, which occur at the same time. An oxidation reaction strips an electron from an atom in a compound, and the addition of this electron to another compound is a reduction reaction. Because oxidation and reduction usually occur together, these pairs of reactions are called redox reactions.
The removal of an electron from a molecule, results in a...
The removal of an electron from a molecule, results in a...
7.8K
Redox Reactions
221
Redox reactions are vital biochemical processes that underpin energy metabolism in cells. These reactions involve the transfer of electrons between molecules, occurring in tandem as oxidation and reduction. Oxidation refers to the loss of electrons, while reduction denotes their gain. This coupling ensures the seamless flow of electrons through metabolic pathways. For example, in bacterial metabolism, glucose undergoes oxidation to carbon dioxide, while oxygen is simultaneously reduced to...
221
Electron Carriers
86.1K
Electron carriers can be thought of as electron shuttles. These compounds can easily accept electrons (i.e., be reduced) or lose them (i.e., be oxidized). They play an essential role in energy production because cellular respiration is contingent on the flow of electrons.
Over the many stages of cellular respiration, glucose breaks down into carbon dioxide and water. Electron carriers pick up electrons lost by glucose in these reactions, temporarily storing and releasing them into the electron...
Over the many stages of cellular respiration, glucose breaks down into carbon dioxide and water. Electron carriers pick up electrons lost by glucose in these reactions, temporarily storing and releasing them into the electron...
86.1K
Electron Behavior
104.7K
Overview
Electrons are negatively charged subatomic particles that are attracted to an orbit around the positively-charged nucleus of an atom. They reside in locations that are associated with energy levels called shells and are further organized into sub-shells and orbitals within each shell.
Electrons Orbit the Nucleus
Electrons are found in specific locations outside of the nucleus. The shell in which an electron resides indicates the general energy level of the electron: those closer to the...
Electrons are negatively charged subatomic particles that are attracted to an orbit around the positively-charged nucleus of an atom. They reside in locations that are associated with energy levels called shells and are further organized into sub-shells and orbitals within each shell.
Electrons Orbit the Nucleus
Electrons are found in specific locations outside of the nucleus. The shell in which an electron resides indicates the general energy level of the electron: those closer to the...
104.7K
Role of Reduced Coenzymes NADH and FADH₂
12.7K
The energy released from the breakdown of the chemical bonds within nutrients can be stored either through the reduction of electron carriers or in the bonds of adenosine triphosphate (ATP). In living systems, a small class of compounds functions as mobile electron carriers, molecules that bind to and shuttle high-energy electrons between compounds in pathways. The principal electron carriers that will be considered originate from the B vitamin group and are derivatives of nucleotides; they are...
12.7K
