后COVID-19 过度炼性心力衰竭:与肺部和心脏的后果的关系
Giovanna Pelà1, Annalisa Frizzelli2, Roberta Pisi3
1Department of Medicine and Surgery, University of Parma, Parma, Italy; Department of General and Specialistic Medicine, University-Hospital of Parma, Parma, Italy.
长期COVID患者的过度运动性心跳动 (EET) 与较差的肺功能有关. 运动期间的氧气不和预测了这种异常的心率反应,突出显示了COVID后的肺部因素.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 后COVID条件 后COVID条件
背景情况:
- 长期的COVID经常与过度运动性心跳动 (EET) 相关,这是后COVID心跳动综合征的潜在表型.
- 在长期COVID患者中导致EET的因素仍未得到充分研究.
研究的目的:
- 在长期COVID-19患者中确定过度运动性心跳动 (EET) 的预测因素.
- 研究心脏病,呼吸道和临床因素与ETE之间的关系.
主要方法:
- 79名长期COVID-19患者接受了全面的心脏和呼吸系统评估.
- 使用6分钟步行测试 (6MWT) 评估了对运动的心率反应,将患者分为EET和正常强迫性心率 (NET) 组.
- 评估包括心声回声,肺扩散能力和氧和度测量.
主要成果:
- 与NET患者相比,EET患者年龄较大,BMI,血压,并发症较高,静止心率较低.
- 在急性阶段,ETT组显示出更高的CT得分和D-二次体水平. 在随访时,他们表现出左心室质量增加和双心室缩/扩张功能减少.
- 在6MWT期间,在EET患者中观察到肺扩散能力和平均氧和量的显著减少. 在6MWT期间的平均氧和量成为异常HR反应的显著预测因素.
结论:
- 长期COVID中运动对心率反应过度与休息期肺功能受损有关.
- 氧气运动诱导的不和是长期COVID患者对运动心率异常反应的关键预测因素.
- 这些发现表明,在长期COVID中,肺功能障碍和心血管失调之间存在联系.
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