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Updated: Sep 19, 2025

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
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A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

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在CXCR4相关的原发性免疫缺陷中,结构和精神运动缺陷的神经发育起源

Giulia Demenego1, Sara Mancinelli1, Antonella Borreca2

  • 1Department of Biomedical Sciences, Humanitas University, Rozzano, Italy; Neurodevelopmental Biology Laboratory, IRCCS Humanitas Research Hospital, Rozzano, Italy.

Neuron
|June 7, 2025
PubMed
概括

免疫的先天性错误 (IEI) 突变直接影响大脑发育,导致独立于免疫问题的神经行为症状. 在WHIM小鼠模型中准Cxcr4可以拯救这些精神运动和情感缺陷.

关键词:
CXCR4CXCR4CXCR4CXCR4CXCR4CXCR4CXCR4CXCR4CXCR4CXCR4C这就是WHIM综合征.小脑小脑是什么意思颗粒细胞是颗粒细胞.免疫缺陷是一种免疫缺陷.免疫的先天错误 免疫的先天错误神经发育的神经发育神经免疫相互作用在plerixafor上使用.心理运动症状 心理运动症状

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