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基化奇多的乳化和稳定能力
Tatiana N Popyrina1, Nadejda A Aksenova2, Anastasia A Shilkova3
1Enikolopov Institute of Synthetic Polymeric Materials RAS, 70 Profsoyuznaya st., Moscow 117393, Russia; Moscow Aviation Institute (National Research University), 4 Volokolamskoe sh., Moscow 125993, Russia.
International journal of biological macromolecules
|June 7, 2025
概括
与未经修改的基托相比,基化基托具有优越的乳化和稳定性,用于制造乳液和可生物降解的微粒. 高度的基化奇托提高了乳液稳定性和微粒的产量.
科学领域:
- 材料科学 材料科学 材料科学
- 聚合物化学 聚合物化学
- 体科学 体科学 体科学
背景情况:
- 酸盐是一种生物聚合物,在药物输送和生物材料中具有潜在的应用.
- 修改基托桑的化学结构可以增强其功能性质.
- 了解乳化和稳定机制对于微粒制造至关重要.
研究的目的:
- 为了比较基化基与未经改性基的乳化和稳定能力.
- 评估基托桑修饰对简单乳液和聚酸微粒的影响.
- 为了研究基托溶液特性与乳液/微粒物质特性之间的关系.
主要方法:
- 使用油/水乳液溶剂蒸发制备简单乳液和聚化物微粒.
- 乳液性质的表征:滴滴大小,大小分布,稳定性,乳化活性和乳化稳定性.
- 微粒子特性分析:产量,大小,形态和表面组成.
- 评估基托桑溶液的特性:粘度,表面张力和水友性脂友性平衡 (HLB).
主要成果:
- 与未经修改的基托相比,基化基托在测试度 (0.5-2 wt%) 中表现出增强的乳化和稳定能力.
- 高度的基化奇托导致乳液稳定性改善,滴滴尺寸缩小,粘度增加,HLB降低,表面张力降低.
- 基化奇托导致了更高的可生物降解微粒总产量,平均尺寸更小.
结论:
- 化显著改善了桑的乳化和稳定性能.
- 基化奇托是一种更有效的乳化剂,用于生产稳定的乳液和高质量的可生物降解微粒.
- 这些发现表明,基化奇托是先进配方和药物输送系统的有前途材料.
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