调节编程细胞死亡的非编码RNA及其对癌症化学疗法耐药性的影响
Meijun Chen1, Peng Zhao1, Jinjiang Chou2
1State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine & Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education & Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, Guiyang 550014, China; Natural Products Research Center of Guizhou Province, Guiyang 550014, China; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 561113, China.
International journal of biological macromolecules
|June 7, 2025
概括
非编码RNAs (ncRNAs) 调节癌细胞死亡,影响化疗耐药性. 针对这些ncRNA编程细胞死亡 (PCD) 途径提供了改善癌症治疗结果的新策略.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 非编码RNAs (ncRNAs),包括microRNAs (miRNAs),长非编码RNAs (lncRNAs),圆形RNAs (circRNAs),PIWI交互RNAs (piRNAs),tRNA衍生小RNAs (tsRNAs) 和小核RNAs (snoRNAs),是癌症的关键调节剂.
- 异常的ncRNA表达涉及到各种编程细胞死亡 (PCD) 途径,如亡,自,铁亡和热亡,影响癌症的进展和治疗反应.
研究的目的:
- 在化学抵抗的背景下,提供一个统一的框架,将六类ncRNA与四种PCD模式联系起来.
- 剖析ncRNAs调节PCD并影响各种癌症类型中药物耐药性的分子机制.
主要方法:
- 系统审查和分析涉及ncRNAs和PCD途径的分子电路.
- 检查ncRNA对酶激活,自流,脂质过氧化和炎症组合的影响.
主要成果:
- ncRNAs复杂地调节了亡,自,铁和热,从而塑造了瘤对化疗的反应.
- 已经确定了特定的ncRNA-PCD相互作用,这些相互作用是各种癌症类型的化学抵抗的基础.
结论:
- 准ncRNA编程细胞死亡 (PCD) 轴对克服化疗耐药性的治疗有希望.
- 解决交付和特异性挑战对于基于ncRNA的癌症疗法的临床转化至关重要.
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