编码ST171的NDM-5Enterobacter hormaechei:一个全球基因组和流行病学视角
Mengting Luo1, Yawen Zhang2, Fang He2
1The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, Zhejiang, China; Department of Clinical Laboratory, Laboratory Medicine Center, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
Journal of global antimicrobial resistance
|June 7, 2025
概括
在全球范围内, blaNDM-5阳性ST171 Enterobacter hormaechei菌株已经出现,特别是在中国和美国. 这些耐卡巴胺菌株在医疗机构内和医疗机构之间呈现克隆性传播,需要持续监测.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 流行病学 流行病学
背景情况:
- 耐卡巴胺的肠道细菌 (CRE) 构成了严重的全球健康威胁.
- 该blaNDM-5基因赋予了对卡巴因的耐药性,这是最后的抗生素类别.
- 肠杆菌hormaechei是一种机会性病原体,经常与医疗保健相关的感染有关.
研究的目的:
- 对携带blaNDM-5基因的ST171 Enterobacter hormaechei分离物进行全面的基因组和流行病学分析.
- 调查这些特定菌株的全球出现和传播模式.
主要方法:
- 使用Illumina技术进行全基因组测序 (WGS).
- 对基因组特征和抗菌素耐药性基因的生物信息分析.
- 用单核酸多态性 (SNP) 数据进行基因组学分析,以确定克隆关系.
主要成果:
- 六种blaNDM-5阳性ST171E.hormaechei菌株从中国的一家紧急重症监护室中分离出来.
- 这些菌株表现出多种药物耐药性,发现了12种抗微生物耐药性基因,包括blaNDM-5.
- 遗传学分析证实了单一的克隆血统,表明了医院传播. 全球搜索发现了75种blaNDM-5阳性ST171 E. hormaechei菌株,主要来自临床来源,在中国和美国的流行率很高,显示在医疗机构中发生克隆传播.
结论:
- blaNDM-5阳性ST171 E. hormaechei菌株代表了一个新兴的全球威胁.
- 医疗机构内部和医疗机构之间的克隆传播强调了需要强有力的感染控制措施的必要性.
- 持续监测对于有效预防和控制与这些菌株相关的抗菌素耐药性至关重要.
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