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可生物降解的Zn-xY合金具有增强的骨质生成和血管生成效应,用于骨植入物应用

Shimin Liang¹, Shaokang Du², Yufeng Zheng²

¹Department of Prosthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing 100081, China; National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing 100081, China.

Acta biomaterialia

|June 7, 2025

概括

这项研究开发了用于骨植入物的可生物降解- (Zn-Y) 合金. -2.0Y表现出优越的机械强度,缓慢的降解,增强骨愈合和血管形成,突出其骨修复的潜力.

科学领域:

生物材料科学生物材料科学
材料工程材料工程材料工程
生物医学工程生物医学工程

背景情况:

可生物降解的基合金对骨植入物来说是有前途的,但需要提高机械性能和生物相容性.
加强骨质分化,血管生成和抗菌性质对于有效的骨植入物材料至关重要.

研究的目的:

开发和系统评估用于骨植入物应用的-xYttrium (Zn-xY) 合金.
研究Zn-xY合金的机械性质,降解行为,细胞相容性,骨质活性,血管生成潜力和抗菌性质.

主要方法:

合成和特征Zn-xY (x = 0.1, 0.6, 1.0, 2.0 在.%) 合金.
在体外研究中评估了细胞相容性,骨质分化 (hBMSCs) 和血管生成 (HUVECs).
在实体大鼠股骨植入研究中,评估了骨整合和抗菌性质.

主要成果:

-2.0Y表现出优越的机械强度 (UTS: 230 MPa,YS: 170 MPa,ER: ~16%) 和最慢的降解率 (45 μm/y).
Zn-2.0Y显著增强了骨质分化,矿化和血管活动.
在体内研究证实,Zn-2.0Y促进了骨的整合,并且与纯相比,具有优越的抗菌特性.
-2.0Y激活PI3K/AKT信号通路,以增强骨质生和血管生活动.

结论:

-2.0Y是一种有前途的可生物降解材料用于骨植入物应用,因为它具有出色的机械性能,可控制的降解,以及促进骨愈合和血管化的能力.
确定PI3K/AKT通路是介导Zn-2.0Y的骨质和血管效益的关键机制.
对Zn-Y合金的进一步研究可能会导致骨缺陷修复和再生的先进解决方案.

关键词:

血管新生的产生.可生物降解的 (Zn) 合金.骨质发生过程 (osteogenesis)通过PI3K/AKT路径.伊特 (Y) 是一种

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