从全球人口中分析人类肠道微生物组数据:挑战和资源
Sabrina J Arif1, Samantha P Graham2, Richard J Abdill1
1Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA.
Trends in microbiology
|June 7, 2025
概括
全球微生物组研究正在扩大,但缺乏多样性. 本综述提供了计算策略,以包括代表性不足的人群,确保从肠道微生物组研究中获得更广泛的健康见解.
科学领域:
- 微生物组研究的研究.
- 计算生物学是一种计算生物学.
- 全球卫生健康 全球卫生健康
背景情况:
- 人类肠道微生物组的研究正在迅速推进.
- 大多数研究来自高收入地区,这限制了概括性.
- 低收入和中等收入国家 (LMICs) 的代表性不足带来了挑战.
研究的目的:
- 解决全球微生物组研究中的计算障碍.
- 为公平和代表性的全球微生物组数据分析提供建议.
- 提高全球微生物组健康协会的普遍性.
主要方法:
- 审查当前的文献和计算挑战.
- 分析参考数据库和元数据中的偏差.
- 检查LMICs基础设施限制的情况.
- 讨论最近的大规模全球采样工作.
主要成果:
- 确定了计算障碍,包括数据库偏差,非代表性元数据和基础设施缺口.
- 强调需要公平的伙伴关系和具有代表性的数据集.
- 强调了在全球范围内对结果进行上下文化的重要性.
结论:
- 未来的研究必须优先考虑包容性和解决计算障碍.
- 公平的全球微生物组研究需要战略伙伴关系和数据管理.
- 克服这些挑战将导致更强大和普遍适用的微生物组健康发现.
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