周围炎症对帕金森病的认知和症状结果的可变影响:纵向和横截面分析
Peikun He1,2, Yanyi Li1,2, Zhiheng Huang1
1Department of Neurology, Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
NPJ Parkinson's disease
|June 7, 2025
概括
通过中性粒细胞与淋巴细胞比率 (NLR) 表示的外周炎症与帕金森病 (PD) 的认知衰退有关. 较高的NLR预测认知功能的恶化,并且与PD患者的白质完整性有关.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 神经学 神经学
背景情况:
- 越来越多的证据表明,外周炎症与帕金森病 (PD) 之间存在联系.
- 周围炎症在PD临床症状进展中的确切作用仍然不完全理解.
研究的目的:
- 在帕金森病患者中使用血清分白细胞计数及其衍生比率来评估周围炎症.
- 研究外周炎症与认知功能,白质完整性和PD疾病进展之间的关联.
主要方法:
- 追溯地招募了GDPH的170名PD患者和PPMI的68名PD患者.
- 对血清分白细胞计数和比率的分析,包括中性粒细胞与淋巴细胞比率 (NLR).
- 部分相关性,纵向分析和路径分析,以评估NLR,认知得分 (MoCA,LNS) 和白质完整性之间的关系.
主要成果:
- 中性粒细胞与淋巴细胞的比率 (NLR) 与GDPH队列中的蒙特利尔认知评估 (MoCA) 有负相关.
- 通过NLR测量的外周炎症与白质完整性相关.
- 较高的基线NLR预测了随着时间的推移,字母数序测序 (LNS) 得分的恶化.
- 白质完整性显著调解了NLR和LNS得分中的认知变化之间的关联.
结论:
- 周围炎症与帕金森病的全球认知和白质完整性有关.
- 升高的NLR是PD患者认知能力下降的潜在预测因素.
- 这些发现强调了外围炎症标志物在PD进展中的临床相关性.
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