阐明Ras蛋白作为炎症和癌症的双重治疗点:一篇评论
Parmar Keshri Nandan1, Jayanthi Sivaraman2
1School of Biosciences and Technology, Vellore Institute of Technology, Vellore, India.
Discover oncology
|June 7, 2025
概括
这篇评论强调了Ras蛋白在癌症发育和炎症中的关键作用. 它探讨了Ras信号,其对免疫力的影响,以及针对癌症Ras突变的新兴治疗策略.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 癌症是由不受调节的炎症和基因突变引起的,Ras瘤基因经常发生突变.
- 瘤性Ras突变物通过炎症途径促进瘤生成,独立于瘤抑制剂的损失.
- 拉斯蛋白是通过细胞外信号激活的膜结合的GTPases,在癌症中驱动异常下游信号.
研究的目的:
- 审查Ras蛋白在癌症和炎症中的重要性.
- 阐明Ras蛋白激活通路,其在免疫力中的作用,以及下游调节者.
- 探索Ras的表观遗传调节,并在各种癌症中确定Ras基因单核酸多态 (SNP).
主要方法:
- 关于Ras蛋白信号传递,免疫力和炎症的文献综述.
- 使用Ras基因SNP的癌症突变蛋白域 (DCMP) 数据库搜索数据库.
- 对表观遗传调节和针对Ras下游途径的抑制剂的分析.
主要成果:
- 拉斯蛋白激活涉及一个信号通路,将其从不活跃形式转换为活跃形式.
- 瘤性Ras突变体在癌症中持续活跃,促进瘤发生.
- 数据库搜索在不同癌症类型的Ras基因中确定了SNP.
结论:
- 拉斯蛋白是癌症和炎症的关键参与者,使其成为一个重要的治疗点.
- 了解Ras信号,调节和突变对于开发新型癌症治疗非常重要.
- 新兴策略的重点是针对Ras蛋白及其相关途径进行癌症治疗.
相关概念视频
02:38The Ras Gene
6.2K
The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
Ras is a...
6.2K
02:23Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
01:24Small GTPases - Ras and Rho
3.9K
Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
Three regulatory proteins control their activity:
Three regulatory proteins control their activity:
3.9K
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
01:07MAPK Signaling Cascades
5.3K
Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
5.3K
01:20The JAK-STAT Signaling Pathway
8.7K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.7K