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高脂肪饮食诱导胃部产生纤维细胞生长因子23 (FGF23)

Patricia Widmayer¹, Martina Feger¹, Leonie Meier¹

¹Department of Physiology, University of Hohenheim, Stuttgart, Germany.

International journal of obesity (2005)

|June 7, 2025

概括

高脂肪饮食刺激胃纤维细胞生长因子23 (FGF23) 的产生,特别是在内皮和上皮细胞中. 这发生在炎症和胃组织完整性受损的同时.

科学领域:

胃肠病学胃肠病学
内分泌学在内分泌学.
细胞生物学细胞生物学

背景情况:

高脂肪饮食 (HFD) 诱导胃炎症和上皮损伤.
纤维细胞生长因子23 (FGF23),一种骨激素,与病理生理条件有关.
众所周知,HFD养可以通过炎症提高血清FGF23水平.

研究的目的:

为了研究HFD养,肥胖和胃FGF23产生的关联.
为了确定肥胖是否影响胃内FGF23的表达.

主要方法:

小鼠接受了短期或长期的HFD.
从小鼠和肥胖患者的胃组织中分析了FGF23的表达.
细胞培养 (HUVEC,GES-1) 用于研究素和IL-1β的FGF23调节.

主要成果:

在小鼠胃中,HFD食增加了Fgf23表达和FGF23蛋白.
在受损的胃部区域发现了FGF23阳性细胞,包括内皮和上皮细胞.
在肥胖患者中检测到胃FGF23,主要在内皮细胞中;素和IL-1β影响了细胞培养中的FGF23表达.

结论:

在胃中,HFD食刺激了FGF23的产生.
肥胖和HFD与胃粘膜中FGF23表达的内皮和上皮细胞增加有关.

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