"这是一个镇静剂吗?" - 一个Delphi集团的过程,以确定切断剂量和剂量间隔的潜在镇静药物在息护理中的切断剂量和剂量间隔
Sabine H Krauss1, Constanze Rémi2, Claudia Bausewein2
1Department of Palliative Medicine, LMU University Hospital, LMU Munich, Marchioninistr. 15, Munich, 81377, Germany. soz@sabinehkrauss.de.
BMC palliative care
|June 7, 2025
概括
这项研究确定了专家同意的息治疗中药物剂量的切断值,以区分与疾病相关的意识减弱和药物诱导的镇静. 这些指导方针有助于有效管理患者镇静和治疗选择.
科学领域:
- 抚慰性护理医学 抚慰性护理医学
- 临床药理学 临床药理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 区分与疾病相关的意识减弱与药物诱导的镇静在息治疗中至关重要.
- 无意镇静需要治疗替代方案,而有意镇静需要遵守指导方针.
- 该iSedPall联盟项目旨在确定药物剂量切断界限,以达到可预测的镇静水平.
研究的目的:
- 建立基于证据和专家共识的药物剂量和剂量间隔的切断值.
- 为了确定预计会引起特定深度镇静或持续作用的门值.
- 帮助临床医生区分疾病相关和药物诱导的镇静.
主要方法:
- 在德国采用了集团德尔菲方法,先后进行了在线调查.
- 文献审查为11种药物的药物切断值的陈述的发展提供了信息.
- 通过在息治疗专家 (医生,药剂师,护士) 之间进行多轮讨论,寻求共识 (≥75%的同意).
主要成果:
- 25/30邀请的专家参与了调查,在Delphi集团中有17名专家.
- 在三轮测试后,所有陈述都达到了共识,确定了10种药物的切断剂量/间隔.
- 这些药物包括洛拉泽帕姆,米达佐拉姆,泽帕姆,莱沃梅普罗玛,哈洛皮多尔,梅尔佩龙,皮帕佩龙,普罗波福尔,德克斯梅托米丁和特拉佐.
结论:
- 这项研究提供了第一个基于证据和专家共识的数据,关于镇静药物在息治疗中的作用.
- 确定的切线值支持临床判断关于常见的息护理药物的镇静潜力.
- 这些发现有助于在息治疗机构安全有效地管理镇静剂.
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