细菌病患者的抗微生物治疗时间为7天而不是14天:随机对照试验的元分析
Marlene Prager1,2, Felix Bergmann1, Lena Pracher1
1Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, 1090, Austria.
Infection
|June 8, 2025
概括
对于细菌病患者来说,与14天持续时间相比,为期7天的抗生素疗程显示出类似的疗效和安全性. 这一发现支持细菌病的抗微生物治疗持续时间更短,可能减少副作用和医疗费用.
科学领域:
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 对细菌病的抗生素治疗的最佳持续时间仍然是一个重要的临床问题.
- 目前的指导方针提供了可变的建议,导致不同的治疗实践.
研究的目的:
- 为了比较7天和14天的抗生素治疗对细菌病的成年患者的疗效和安全性.
- 为临床决策提供有关细菌病管理中的抗菌药物管理的信息.
主要方法:
- 进行了随机对照试验 (RCT) 的元分析.
- 搜索了对抗细菌病患者7天和14天抗微生物治疗方案进行比较的RCT,直到2024年12月.
- 评估结果包括90天死亡率,细菌病复发,住院和不良事件.
主要成果:
- 包括4个RCT,共有4790名参与者.
- 在90天全因死亡率 (RR 0.93;95% CI,0.81-1.07) 中没有发现显著差异.
- 平均住院时间,细菌病复发和安全结果 (不良事件,C. difficile感染,AKI,皮疹) 在7天和14天组之间是可比的.
结论:
- 长达7天和14天的抗微生物治疗表明,对细菌病的疗效和安全性表现相似.
- 较短的抗生素持续时间可能是治疗细菌病的可行选择,在临床实践中需要考虑.
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