患有高尿血症的患者的泛免疫-炎症价值:基于人口的研究.
Qian Zhang1, Lin Li1, Jing Zhou1
1Department of Endocrinology, Rheumatology and Immunology, PLA Rocket Force Characteristic Medical Center, Beijing, 100088, China.
Clinical rheumatology
|June 8, 2025
概括
泛免疫炎症值 (PIV) 与高尿路血的患病率和风险更高有关. 升高的PIV也增加了所有原因和心血管死亡的风险在患有高尿路血的人.
科学领域:
- 生物标志物和公共卫生
背景情况:
- 系统性炎症与各种慢性疾病有关.
- 全免疫炎症值 (PIV) 是一种反映系统性炎症的新兴生物标志物.
- 超尿路血是与心血管风险增加相关的疾病.
研究的目的:
- 调查美国成年人中PIV和高尿路血症患病率之间的关联.
- 检查PIV与高尿路血的风险之间的关系.
- 评估PIV对高尿血症患者全因和心血管死亡率的影响.
主要方法:
- 利用了2007-2018年国家健康和营养检查调查 (NHANES) 的数据.
- 使用中性细胞,血小板,单细胞和淋巴细胞计数计算PIV.
- 根据男性和女性确定的尿酸水平值,定义了超尿血症.
主要成果:
- 总共有31,151名参与者被分析.
- 高尿路血症的患病率随着PIV水平的提高而增加 (P < 0.001).
- 较高的PIV四分位数与高尿素血的风险增加有关 (OR = 1.19,P = 0.001),显示出剂量反应关系.
- 增加的PIV与高尿血病患者全因和心血管死亡率的增加相关 (P < 0.001).
结论:
- PIV是评估免疫-炎症反应的潜在流行病学工具.
- PIV可能有助于评估超尿血症风险及其预后影响.
- 该研究强调了PIV在理解高尿血和相关死亡风险方面的作用.
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