瘤微环境和免疫疗法:从长椅到床边
Avipsa Sinha1, Debasmita Ghosh2, Dipanjan Karati3
1Department of Pharmaceutical Technology, BCDA College of Pharmacy and Technology, Campus-2, Ghosh Para Road, Madhyamgram, Kolkata, 700129, West Bengal, India.
Medical oncology (Northwood, London, England)
|June 8, 2025
概括
瘤微环境 (TME) 影响癌症的进展和治疗耐药性. 重编程TME的策略可以提高免疫治疗对瘤的有效性.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
背景情况:
- 瘤微环境 (TME) 包括影响癌症的细胞和细胞外成分.
- TME的特征包括异常的血管结构,改变的细胞外基质,以及像纤维细胞和巨细胞这样的免疫细胞.
- TME的免疫抑制性阻碍了有效的癌症治疗和免疫疗法.
研究的目的:
- 探索TME在癌症发病,进展和治疗耐药性的作用.
- 审查针对TME重编程以增强抗瘤反应的新型免疫治疗策略.
- 讨论通过调节TME来提高癌症免疫治疗疗效的新兴方法.
主要方法:
- 关于瘤微环境组件和功能的当前文献的综述.
- 分析TME内部的免疫抑制机制,包括调节性T细胞和检查点分子表达.
- 检查针对TME调制的新型治疗策略.
主要成果:
- TME显著影响癌症进展和免疫治疗结果.
- 在TME中的免疫抑制元素,如MDSCs和PD-L1,促进瘤存活.
- 像免疫检查点阻塞 (ICB),CAR-T细胞疗法和型病毒这样的新疗法在重塑TME方面表现有前途.
结论:
- 重新编程瘤微环境对于克服治疗耐药性至关重要.
- 针对TME组件可以提高现有和新型免疫疗法的疗效.
- 新兴的TME调节策略为有效的癌症治疗提供了新的途径.
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