在卵内刺激训练天生的免疫力,以减轻肉中Campylobacter jejuni的感染
Ramesha N Wishna-Kadawarage1, Rita M Hickey2, Maria Siwek1
1Department of Animal Biotechnology and Genetics, Faculty of Animal Breeding and Biology, Bydgoszcz University of Science and Technology, Mazowiecka 28, Bydgoszcz, 85-084, Poland.
Poultry science
|June 8, 2025
概括
用益生菌或益生菌进行卵内刺激可以训练肉的天生的免疫力. 这种方法有效地减少了Campylobacter jejuni在肠道中的殖民,为这种动物传染病原体提供了一种新的控制策略.
科学领域:
- 禽畜科学 禽畜科学 禽畜科学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 坎皮洛巴克是欧洲领先的动物传染病原体,在肉的控制是一个重要的科学重点.
- 之前的研究表明,使用益生菌 (Leuconostoc mesenteroides B/00288) 和预防性益生菌 (益生菌+大提取物) 进行卵子内刺激,可以减少Campylobacter jejuni的殖民.
研究的目的:
- 为了研究在卵子刺激后肉的生理和基因组反应.
- 阐明在Ceca.的Campylobacter减少背后的机制.
- 评估in-ovo刺激对肠道微生物群和宿主免疫力的影响.
主要方法:
- 定量PCR (qPCR) 检测细菌群体的丰富性和免疫基因表达.
- 使用PAS染色方法对结组织进行基因组学分析.
- 与酶相关的免疫吸收试验 (ELISA) 用于血清免疫球蛋白Y (IgY) 的量化.
主要成果:
- 这两种治疗都减少了Akkermansia sp. 丰富;益生菌治疗减少了Bifidobacterium sp. 的存在. 在受感染的中.
- 在卵内刺激上调节了桃体和脏中的先天免疫基因表达.
- 在刺激组中,状组织形态学显示状的宽度和密室深度下降;血清IgY水平保持不变.
结论:
- 在卵内刺激会激发肉的先天免疫力.
- 这种方法在控制Campylobacter jejuni殖民方面表现出有效性.
- 在卵内激活是一种有前途的策略,用于控制家禽生产中的坎皮洛巴克特菌.
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