维生素D缺乏:在COVID-19中抗体下降的危险因素?
Luciana Paola Bohl1, María Laura Breser1, Gabriela Edith Aguirre1
1Instituto Multidisciplinario de Investigación y Transferencia Agroalimentaria y Biotecnológica (IMITAB CONICET-UNVM). Campus Universitario, Av. Arturo Jauretche 1555. Villa María, Córdoba 5900, Argentina; Instituto Académico Pedagógico de Ciencias Básicas y Aplicadas, Universidad Nacional Villa María (UNVM). Campus Universitario, Av. Arturo Jauretche 1555. Villa María, Córdoba 5900, Argentina.
概括
维持足够的维生素D水平对于持续的SARS-CoV-2 (COVID-19) 抗体反应至关重要. 接种疫苗可以显著提高抗体水平,而缺乏疫苗会影响长期免疫力.
科学领域:
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 维生素D缺乏与增加呼吸道感染的风险和严重程度有关.
- 营养和内分泌因素影响对SARS-CoV-2 (COVID-19) 的免疫反应.
研究的目的:
- 评估25-基维生素D (25(OH) D水平对SARS-CoV-2 (COVID-19) 特定免疫球蛋白G (IgG) 抗体反应的影响.
- 探索抗体水平与症状,并发症和疫苗接种状况等因素之间的关联.
主要方法:
- 在阿根廷对131名成人SARS-CoV-2 (COVID-19) 阳性患者进行了长度研究.
- 收集了关于维生素D水平,症状,并发症,疫苗接种和抗体标位在诊断时,诊断后30天和180天的数据.
主要成果:
- 65%的患者的维生素D水平较低;那些患有先前存在的疾病的人的维生素D水平较低.
- 诊断后30天观察到的最高抗体水平;接种疫苗的患者的抗体水平更高.
- 在维生素D缺乏的患者中,抗体水平在30至180天之间显著下降.
结论:
- 适当的维生素D水平对于对SARS-CoV-2 (COVID-19) 持续的幽默免疫反应至关重要.
- 接种疫苗可以提高针对SARS-CoV-2 (COVID-19) 的特定抗体水平.
- 治疗症状的药物使用与较低的抗体水平有关.
相关概念视频
01:23Role of Skin in Vitamin D Synthesis
5.8K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.8K
01:26Factors Affecting the Risk of Infection
12.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.3K
01:25Role of Vitamins in Maintaining Bone Health
3.7K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.7K
01:30Vitamins
1.0K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
1.0K
01:29Pulmonary Tuberculosis I
335
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
335
01:36Humoral Immune Responses
77.1K
Overview
77.1K