估计的葡萄糖处置率与心血管疾病风险在不同类型的萨尔科佩尼亚状态之间之间的关联:回顾性队列研究
Xiongmu Tan1, Xiaoqin Chen1, Yanrui Shen1
1Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Clinical nutrition ESPEN
|June 8, 2025
概括
较高的估计葡萄糖处置率 (eGDR) 与老年人心血管疾病 (CVD) 风险降低有关. 这种保护性关联在患有和没有肉症的个体中观察到,突出显示了eGDR.
科学领域:
- 老年学是一门学科.
- 心脏病学 心脏病学
- 代谢健康 代谢健康
背景情况:
- 胰岛素抵抗 (IR) 与心血管疾病 (CVD) 风险有关.
- 估计的葡萄糖处置率 (eGDR) 作为IR的可靠标志物.
- 肉症,肌肉质量和力量的损失,与诸如心血管疾病等慢性疾病相互作用.
研究的目的:
- 调查eGDR,肉症和心血管疾病发病率之间的关联.
- 探索eGDR如何影响中年和老年人群中的心血管疾病风险.
- 分析心血管疾病风险,按肉症状况和eGDR水平分层.
主要方法:
- 在基线无心血管疾病的5938名参与者的分析.
- 包括肉症指标和eGDR数据.
- 利用卡普兰-梅尔曲线,考克斯模型和子组分析来评估在8.14年的随访期间的心血管疾病事件发生率.
主要成果:
- 记录了19.6%的心血管事件的发生率.
- 增加的EGDR水平与心血管疾病风险降低相关.
- 对于心血管疾病的危险比率在更高的eGDR四分位数 (Q2-Q4与Q1) 中显著较低,而不管是肉症状态.
结论:
- 升高的eGDR与老年人心血管疾病风险降低有显著关联.
- 这种关联对非sarcopenic和sarcopenic个体都适用.
- eGDR是预测老年人群心血管疾病风险的一个有价值的指标.
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