大脑小血管疾病中的神经血管合变化:对认知障碍的多次延迟ASL和fMRI视角
Peng Zeng1, Bang Zeng1, Dan Luo1
1Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Magnetic resonance imaging
|June 8, 2025
概括
神经血管脱在脑小血管疾病 (CSVD) 中显而易见. 特定的成像指标有效地对有或没有认知障碍的CSVD患者进行分类,帮助诊断.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 血管生物学 血管生物学
背景情况:
- 大脑小血管疾病 (CSVD) 影响神经血管合 (NVC).
- 了解NVC变化及其与认知状态的关系在CSVD中至关重要.
- 现有的神经成像指标需要进一步评估CSVD的临床实用性.
研究的目的:
- 在CSVD患者中调查NVC的变化.
- 探索神经成像指标和临床评估之间的关系.
- 确定有效的分类指标,以区分CSVD患者亚组.
主要方法:
- 参与者被分为健康的对照组,具有正常认知的CSVD和具有认知障碍的CSVD.
- 用动脉传输时间 (ATT) 校正的大脑血流 (CBF) 和低频波动幅度 (ALFF/dALFF) 来评估神经血管合.
- 使用多变量模式分析来确定分类的有效性.
主要成果:
- 与对照组相比,CSVD患者的交叉声细胞相关性较低,在感觉运动皮质,边缘系统和基底质中出现异常.
- 在受影响的大脑区域的临床评估得分和NVC指标之间发现了显著的相关性.
- CBF/ALFF比率有效地区分了健康对照和正常认知的CSVD,而dALFF和CBF则区分了正常认知和受损认知的CSVD患者.
结论:
- 神经血管脱存在于CSVD中,可以通过ATT纠正的CBF,dALFF和ALFF识别.
- 神经成像指标的特定组合表明,基于认知状态对CSVD患者的分类具有前途.
- 这些发现可能会增强CSVD的诊断和治疗策略.
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