长期禁食及其对炎症生物标志物的影响:全面的范围审查
Isabella de Ciutiis1, Shadia Djakovic1, Maria Lastra Cagigas1
1Charles Perkins Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Ageing research reviews
|June 8, 2025
概括
长时间禁食 (≥48小时) 可能会增加炎症,这与普遍认为的相反. 虽然一些研究显示了短暂的变化,但对其对代谢健康的长期影响需要更多的研究.
科学领域:
- 营养科学 营养科学
- 代谢健康 代谢健康
- 炎症研究的研究.
背景情况:
- 长时间的禁食越来越受欢迎,但其对炎症的影响尚不清楚.
- 据称禁食可以减少炎症,因此需要对科学证据进行审查.
研究的目的:
- 系统地审查长时间禁食 (≥48小时) 对关键炎症生物标志物的影响.
- 检查C反应性蛋白 (CRP),IL-6 (IL-6) 和瘤缩因子-α (TNF-α) 的变化.
主要方法:
- 按照PRISMA-ScR指南进行系统范围审查.
- 搜索的主要数据库 (PubMed,Medline,科学网,Embase,Scopus) 截至2024年8月.
- 包括长时间禁食和炎症标志物的同行评审的人类临床试验.
主要成果:
- 14项研究符合纳入标准;大多数没有改变或增加炎症生物标志物.
- 在禁食期间,C-反应蛋白 (CRP) 经常上升,特别是在超重/肥胖个体中.
- 干白素-6 (IL-6) 和瘤亡因子-α (TNF-α) 的增加不太一致;观察到一些禁食后的正常化.
结论:
- 关于长时间禁食的炎症影响的证据有限且不一致.
- 长时间的禁食似乎会增加炎症,可能是一种适应性反应.
- 进一步的研究,包括RCT,对于了解对炎症和代谢疾病的长期影响至关重要.
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