暴露从神经发育到神经退行:一个叙事审查
Sveva Dallere1, Daniela Maria Rasà1, Gianna Pavarino2
1Neuroscience Institute Cavalieri Ottolenghi, Department of Neuroscience "Rita Levi Montalcini", University of Turin, Turin, Italy; University School for Advanced Studies IUSS Pavia, Pavia, Italy.
Neuroscience and biobehavioral reviews
|June 8, 2025
概括
暴露组,包括所有终身暴露,从发育到衰老和神经退行,显著影响大脑健康. 了解这些环境因素是预防神经系统疾病的关键.
科学领域:
- 环境健康科学 环境健康科学
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- "暴露体"概念整合了从受孕到整个生命的所有环境暴露.
- 这些暴露越来越多地被认为对人类健康有着深刻的影响.
- 中枢神经系统 (CNS) 特别容易受到生活各个阶段的环境影响.
研究的目的:
- 为了提供一个全面的概述曝光体对大脑健康的影响在人类的寿命.
- 探索不同暴露组域 (一般外部,特定外部,内部) 与中枢神经系统功能之间的相互作用.
- 突出暴露学在理解和预防神经系统疾病中的作用.
主要方法:
- 对2005年至2024年间发表的开放获取文章进行叙述性审查.
- 搜索术语包括"暴露体"",中枢神经系统"和生命阶段 (怀孕,童年,成年,衰老,神经退行).
- 分析的重点是研究检查所有生命阶段的特定暴露组域,包括具有机械洞察力的人类和实验数据.
主要成果:
- 暴露组影响中枢神经系统的发育,成年期的功能,生理衰老和神经退行性疾病.
- 特定的环境因素,包括化学物质和生活方式选择,可以对中枢神经系统产生有害和有益的影响.
- 一般外部,特定外部和内部暴露组域之间的相互联系对于理解整体大脑健康至关重要.
结论:
- 暴露学框架为制定公共卫生政策和神经系统疾病预防策略提供了巨大的潜力.
- 跨学科的方法对于解决影响中枢神经系统健康的复杂环境决定因素至关重要.
- 进一步的研究将终身暴露与神经现象类型联系起来,对于推进个性化医学和公共卫生干预至关重要.
相关概念视频
01:37Neural Regulation
40.4K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
40.4K
01:15Neurogenesis and Regeneration of Nervous Tissue
1.1K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.1K
01:27Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
1.0K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
1.0K