瘤缩因子α诱导的SREBP2激活促进胆固醇在胆固醇中胆固醇的生物合成

Ziqian Xu1, Xinyu Cao1, Zhixian Zhu1

  • 1Department of Gastroenterology, The First Affiliated Hospital (Southwest Hospital) of Third Military Medical University (Army Medical University), Chongqing, China; Institute of Digestive Diseases of PLA, Third Military Medical University (Army Medical University), Chongqing, China; Cholestatic Liver Diseases Center, The First Affiliated Hospital (Southwest Hospital) of Third Military Medical University (Army Medical University), Chongqing, China; Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Medical Research Center, The First Affiliated Hospital (Southwest Hospital) of Third Military Medical University (Army Medical University), Chongqing, China.

概括

胆固醇酶通过激活TNFα来增加胆固醇,TNFα通过激活TNFα来调节醇调节元素结合蛋白2 (SREBP2). 用Fatostatin抑制SREBP2在小鼠模型中减少了肝损伤,这表明了一个新的治疗点.

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